But Manchester City can regain top of the EPL table if they win their game in hand at Burnley on Sunday.
The Reds went in front through Naby Keita’s goal after 15 seconds, as the Guinea midfielder swept a close-range effort into the bottom left corner from Salah’s pass to record Liverpool’s quickest goal in a Premier League match.
Concise News understands that it was also Liverpool’s 100th goal in all competitions this season.
Mane later made it 2-0 when he glanced Andrew Robertson’s superb cross into the bottom right corner.
Salah then increased the lead as he lobbed Huddersfield goalkeeper Jonas Lossl on the stroke of half-time, before Mane headed in his second from Jordan Henderson’s cross.
Salah found the back of the net in the closing stages to move on to 21 goals, sealing a fine team performance.
Jurgen Klopp’s men now have 91 points, two more than second-placed City.
After the match, here is the updated EPL table: