It is a much-anticipated match as Barcelona have an advantage after taking a 1-0 lead at Old Trafford last Wednesday.
But like they did against Paris Saint-German, overturning a two-goal deficit at Parc de France, Ole Gunnar Solskjaer and his men will hope to get the better of Barca in front of their fans at Camp Nou.
United’s trip to Camp Nou comes almost 20 years to the day that Solskjaer scored an injury-time goal against Bayern Munich to help United win their second Champions League title.
Manchester United Team News
Ole Gunnar Solskajer might have no other choice than to likely revert Ashley Young to the left flank and wing-back after Luke Shaw got suspended for the second leg.
Out: Bailly (concussion), Herrera (thigh), Shaw (suspended), Valencia (calf)
Misses next match if booked: Herrera, Matić, Valencia, Young
Barcelona Team News
Ousmane Dembele might be included in the starting line-up but might come in the second half.
Dembele started in Barca’s 1-1 draw at Huesca on Saturday, so should have a bench role against United.
Messi was rested at the weekend along with the likes of Philippe Coutinho, Nelson Semedo, Clement Lenglet, Sergio Busquets, Gerard Pique, Jordi Alba and Luis Suarez, who will all likely start in Europe.
Out: Rafinha (knee)
Doubtful: Vermaelen (hamstring)
Misses next match if booked: Busquets, Semedo
Barcelona vs Man United Possible Line-ups
Barcelona XI: Ter Stegen, Semedo, Pique, Lenglet, Alba, Busquets, Roberto, Rakitic, Arthur, Messi, Suarez
Man Utd XI: Dalot, Smalling, Lindelof, Young, McTominay, Fred, Pogba, Lukaku, Rashford, Lingard